Chloroplast Degradation: Multiple Routes Into the Vacuole

The Vacuole Import and Degradation Pathway Converges with the Endocytic Pathway to Transport Cargo to the Vacuole for Degradation

Computing Multiple Watchman Routes

We present heuristics to compute multiple watchmen routes. Given a polygon (with or without holes) and a parameter k, we compute a set of k routes inside the polygon such that any point inside the polygon is visible from at least one point along one route. We measure the quality of our solutions by either the length of the longest route and the sum of route lengths, where the goal is to minimiz...

New Routes into the Human Brain

The combination of human genetics, animal models, and induced pluripotent stem cells is likely to revolutionize our understanding of neuropsychiatric disorders, leading to new therapies and insights into how the normal human brain works. This is the territory I would explore if I were starting my research career today.

Import of proteins into the chloroplast lumen.

Plastocyanin is a nuclear-encoded protein that is functional in the thylakoid lumen of the chloroplast. It is synthesized in the cytoplasm as a precursor with an N-terminal transit peptide of 66 amino acids. Its transport route involves two steps, import into the chloroplasts and subsequent routing over the thylakoid membrane into the lumen. Concomitant with the transport, the transit peptide i...

Hitchhiking vesicular transport routes to the vacuole: Amyloid recruitment to the Insoluble Protein Deposit (IPOD)

Sequestration of aggregates into specialized deposition sites occurs in many species across all kingdoms of life ranging from bacteria to mammals and is commonly believed to have a cytoprotective function. Yeast cells possess at least 3 different spatially separated deposition sites, one of which is termed "Insoluble Protein Deposit (IPOD)" and harbors amyloid aggregates. We have recently disco...